Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity
نویسندگان
چکیده
منابع مشابه
Paraneoplastic cerebellar degeneration and anti-Yo antibodies.
a Servicio de Neurología, Hospital Universitario La Fe, Valencia, Spain b Laboratorio de Neurología Experimental, Centro de Investigación, Hospital Universitario La Fe; Valencia, Spain and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) c Servicio de Neurología, Hospital Santa Maria del Rosell, Cartagena, Murcia, Spain d Servicio de Anatomía Patológica,...
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The ataxic syndrome associated with Anti-Yo antibody, or Purkinje cell cytoplasmic antibody type 1 (PCA1), is the most common variant of paraneoplastic cerebellar degeneration (PCD). The typical presentation involves the subacute development of pancerebellar deficits with a clinical plateau within 6 months. The vast majority of cases have been reported in women with pelvic or breast tumors. Mag...
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We reviewed the clinical findings in 55 patients with cerebellar degeneration associated with the anti-Yo antibody (an anti-Purkinje cell antibody identified in this study by histochemistry and Western blot). The patients were all women, 26 to 85 years old. Fifty-two of them proved to have malignancies, almost exclusively breast or gynecologic cancers and usually confined to the involved organs...
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RATIONALE Rehabilitation for paraneoplastic cerebellar degeneration (PCD) has been indicated as necessary. However, there are only a few reports on rehabilitation in PCD. We describe the course of physical and cognitive functions and activities of daily living (ADL) in a patient with PCD and examine the effect of rehabilitation, along with a review of relevant literature. PATIENT CONCERNS A 4...
متن کاملAnti-Yo antibody-mediated paraneoplastic cerebellar degeneration in a female patient with pleural malignant mesothelioma.
Paraneoplastic cerebellar degeneration is a rare non-metastatic complication of malignancies. It presents with acute or subacute onset of ataxia, dysarthria and intention tremor. Paraneoplastic cerebellar degeneration is most commonly associated with malignancies of the ovary, breast and lung. The anti-Yo (anti-Purkinje cells) antibodies that specifically damage the Purkinje cells of the cerebe...
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ژورنال
عنوان ژورنال: Neuropathology and Applied Neurobiology
سال: 2018
ISSN: 0305-1846
DOI: 10.1111/nan.12492